| Autor: |
Monterroso, Begoña, Zorrilla, Silvia, Sobrinos-Sanguino, Marta, Robles-Ramos, Miguel Ángel, Alfonso, Carlos, Söderström, Bill, Meiresonne, Nils Y., Verheul, Jolanda, den Blaauwen, Tanneke, Rivas, Germán |
| Zdroj: |
mBio; June 2019, Vol. 10 Issue: 3 |
| Abstrakt: |
The division of an E. colicell into two daughter cells with equal genomic information and similar size requires duplication and segregation of the chromosome and subsequent scission of the envelope by a protein ring, the Z-ring. MatP is a DNA binding protein that contributes both to the positioning of the Z-ring at midcell and the temporal control of nucleoid segregation. Our integrated in vivoand in vitroanalysis provides evidence that MatP can interact with lipid membranes reproducing the phospholipid mixture in the E. coliinner membrane, without concomitant recruitment of the short DNA sequences specifically targeted by MatP. This observation strongly suggests that the membrane may play a role in the regulation of the function and localization of MatP, which could be relevant for the coordination of the two fundamental processes in which this protein participates, nucleoid segregation and cell division. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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