| Autor: |
Kanchugal P, Sandesh, Selmer, Maria |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; March 2020, Vol. 64 Issue: 6 |
| Abstrakt: |
Spectinomycin is a ribosome-binding antibiotic that blocks the translocation step of translation. A prevalent resistance mechanism is modification of the drug by aminoglycoside nucleotidyl transferase (ANT) enzymes of the spectinomycin-specific ANT(9) family or by enzymes of the dual-specificity ANT(3ʺ)(9) family, which also acts on streptomycin. We previously reported the structural mechanism of streptomycin modification by the ANT(3ʺ)(9) AadA from Salmonella enterica. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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