| Autor: |
Burka, ER, Ballas, SK, Sabesin, SM |
| Zdroj: |
Blood; January 1975, Vol. 45 Issue: 1 p21-27, 7p |
| Abstrakt: |
Exposure of rabbit or human erythrocytes to concentrations of puromycin as low as 7 x 10(-4)M for 2 hr causes damage to the cell membrane, as evidenced by increased susceptibility of the cells to hyposmotic lysis, increased cell rigidity, and ultrastructural changes consistent with severe membrane damage. Puromycin causes a concentration-dependent internalization of the erythrocyte membrane, resulting in vacuolization of the cells, at concentrations between 7 x 10(-4) M and 10(-2) M. Since the erythrocyte does not synthesize protein, the data indicate that puromycin has a direct toxic effect on erythroid cell membranes which is unrelated to its action in inhibiting the synthesis of protein. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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