Leukocyte Antigen-Antibody Reaction and Lysis of Paroxysmal Nocturnal Hemoglobinuria Erythrocytes

Autor: SIRCHIA, GIROLAMO, FERRONE, SOLDANO, MERCURIALI, FRANCESCO
Zdroj: Blood; September 1970, Vol. 36 Issue: 3 p334-336, 3p
Abstrakt: The interaction between leukocyte antigens and specific antibodies can cause lysis of the red cells of paroxysmal nocturnal hemoglobinuria (PNH) in vitro. It is suggested that the activation of complement ensuing from the antigen-antibody interaction is responsible for PNH cell lysis. The clinical implications of this finding are briefly outlined.
Databáze: Supplemental Index