The Effects of Acute Protein Depletion on the Distribution of Radioiron in Rat Tissues

Autor: BETHARD, W. F., WISSLER, R. W., THOMPSON, J. S., SCHROEDER, M. A., ROBSON, M. J.
Zdroj: Blood; February 1958, Vol. 13 Issue: 2 p146-155, 10p
Abstrakt: 1. The distribution of Fe59 in plasma, bone marrow, erythrocytes, liver, and spleen was determined at specified intervals after single intravenous injections of the radioisotope into normal and protein-deficient rats. 2. In normal rats, injected radioiron followed the usual metabolic pathways; i.e., through bone marrow to erythrocytes, with small, consistent amounts to liver and spleen. 3. In protein-deficient animals normal Fe59 time-concentration relationships were disrupted completely. 4. Less iron was recovered from the tissues of protein-deficient rats than from normal animals. 5. Storage iron in liver and spleen was not conjugated with polysaccharide, even though tissue protein was seriously depleted.
Databáze: Supplemental Index