| Autor: |
Luppi, Mario, Barozzi, Patrizia, Santagostino, Gaia, Trovato, Raffaella, Schulz, Thomas F., Marasca, Roberto, Bottalico, Davide, Bignardi, Lucia, Torelli, Giuseppe |
| Zdroj: |
Blood; November 2000, Vol. 96 Issue: 9 p3279-3281, 3p |
| Abstrakt: |
In transplant patients, Kaposi sarcoma (KS)-associated herpesvirus or human herpesvirus-8 (HHV-8) infection is associated with the development of KS, primary effusion lymphoma and Castleman disease. Whether HHV-8 is either reactivated in the recipient or transmitted by the donor has been investigated so far only by serologic studies. Thus, we addressed the issue of HHV-8 transmission in the transplantation setting by molecular methods. We exploited the high level variability of the orf-K1 gene and the polymorphism of theorf-73 gene of the HHV-8 genome to assess the genetic relatedness of the HHV-8 strains identified in the posttransplant KS lesions that developed, simultaneously, 20 months after transplantation, in 2 recipients of twin kidneys from the same cadaver donor. The 100% identity of nucleotide sequence of the most variable viral region and the presence of the same, singleorf-73 type in both patients provides strong molecular evidence of organ-related transmission of HHV-8 in the setting of transplantation. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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