| Autor: |
Kitchingman, GR, Rovigatti, U, Mauer, AM, Melvin, S, Murphy, SB, Stass, S |
| Zdroj: |
Blood; March 1985, Vol. 65 Issue: 3 p725-729, 5p |
| Abstrakt: |
We studied the arrangement of the immunoglobulin heavy chain genes by Southern blot analysis of DNA freshly obtained from marrow blast cells of 14 children with T cell acute lymphoblastic leukemia (T-ALL) using probes to the C mu and JH gene segments: At least one of the C mu-gene alleles was rearranged in three cases. In two of these, one C mu gene had the germ-line configuration and one was rearranged, whereas both alleles were rearranged in the third case. In one case, a rearranged heavy chain gene hybridized to the C mu-region probe, but not to the JH probe, indicating that the entire JH region had been deleted. These results demonstrate that immunoglobulin heavy chain gene rearrangements are not restricted to B lineage lymphoproliferative diseases in humans. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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