| Autor: |
Chen, Xiaoyu, Lai, Nathanael Chun-Him, Wei, Kongchang, Li, Rui, Cui, Miao, Yang, Boguang, Wong, Siu Hong Dexter, Deng, Yingrui, Li, Jiashen, Shuai, Xintao, Bian, Liming |
| Zdroj: |
ACS Nano; April 2020, Vol. 14 Issue: 4 p4027-4035, 9p |
| Abstrakt: |
Dynamic controlling the nanoscale presentation of synergistic ligands to stem cells by biomimetic single-chain materials can provide critical insights to understand the molecular crosstalk underlying cells and their extracellular matrix. Here, a stimuli-responsive single-chain macromolecular nanoregulator with conformational dynamics is fabricated based on an advanced scale-up single polymeric chain nanogel (SCNG). Such a carefully designed SCNG is capable of mediating a triggered copresentation of the master and cryptic ligands in a single molecule to elicit the synergistic crosstalk between different intracellular signaling pathways, thereby considerably boosting the bioactivity of the presented ligands. This controllable nanoswitching-on of cell-adhesive ligands’ presentation allows the regulation of cell adhesion and fate from molecular scale. The modular nature of this synthetic macromolecular nanoregulator makes it a versatile nanomaterial platform to assist basic and fundamental studies in a wide array of research topics. |
| Databáze: |
Supplemental Index |
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