Investigating the ameliorative effects of the aqueous extract of Pleurotus ostreatuson cyclophosphamide-induced cytotoxicity in rabbits

Autor: Rowaiye, Adekunle B., Omobowale, Temidayo, Salami, Suliat A., Asala, Titilayo M., Oni, Solomon O., Aiyedoju, Augustine, Peters, Sonny O., Bukoye, Rukayat O., Ukpong, John E.
Zdroj: Toxicology and Environmental Health Sciences; 20240101, Issue: Preprints p1-13, 13p
Abstrakt: Objective: This study investigated the ameliorative effect of aqueous extract of Pleurotus ostreatus(APO) against cyclophosphamide-induced cytotoxicity in rabbits. Methods: Seventy-two healthy rabbits were divided into eight groups each with nine rabbits. Rabbits in groups 1, 2, 3 and 4 (CPA-treated groups) were each given a single oral dose of 50 mg/kg of cyclophosphamide (CPA), however rabbits in groups 2, 3 and 4 were post-treated with 5.0, 7.5 or 10 mg/kg APO on day 1 and throughout the experiment. Rabbits in groups 5, 6, 7 and 8 (CPA-untreated groups) were given only 0.0, 5.0, 7.5 and 10 mg/kg APO per day, respectively throughout the experiment. The experiment lasted 15 days. Serum chemistry analyses and histopathological examination of liver tissues were carried out. Results: Serum creatinine, bilirubin, globulin and total protein concentrations observed in CPA-treated groups were higher (P< 0.05) than those of CPA-untreated groups. Highest (P< 0.05) values for total protein (83.60 g/dl) and globulin (43.16 g/dl) were recorded in CPA-treated groups administered 10.0 mg/kg APO per day. Haematological measurements (packed cell volume, haemoglobin, white blood cell, platelet and red blood cells) in CPA-treated groups were lower (P< 0.01) in comparison to those of CPA-untreated groups. However, an increase (P< 0.01) in the values of these parameters was observed following post-treatment of rabbits in the CPA-treated groups with 7.5 and 10.0 mg/kg APO per day. Conclusion: The findings of this study thus indicate that aqueous extract of Pleurotus ostreatushas the potential to ameliorate CPA-induced renal injury and myelosuppression in a dose-dependent manner.
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