Increased Chitotriosidase Is Associated With Aspergillusand Frequent Exacerbations in South-East Asian Patients With Bronchiectasis

Autor: Poh, Tuang Yeow, Tiew, Pei Yee, Lim, Albert Yick Hou, Thng, Kai Xian, Binte Mohamed Ali, Nur A’tikah, Narayana, Jayanth Kumar, Mac Aogáin, Micheál, Tien, Zhijun, Chew, Wui Mei, Wai Chan, Adrian Kwok, Keir, Holly R., Dicker, Alison J., Hassan, Tidi Maharani, Xu, Huiying, Tee, Augustine K.H., Ong, Thun How, Koh, Mariko Siyue, Abisheganaden, John Arputhan, Chalmers, James D., Chotirmall, Sanjay H.
Zdroj: Chest; August 2020, Vol. 158 Issue: 2 p512-522, 11p
Abstrakt: Chitinase activity is an important innate immune defence mechanism against infection that includes fungi. The 2 human chitinases: chitotriosidase (CHIT1) and acidic mammalian chitinase are associated to allergy, asthma, and COPD; however, their role in bronchiectasis and bronchiectasis-COPD overlap (BCO) is unknown.
Databáze: Supplemental Index