| Autor: |
Huang, Liyi, Wang, Min, Sharma, Sulbha, Sperandio, Felipe, Maragani, Satya, Nayka, Suhasini, Chang, Julie, Hamblin, Michael, Chiang, Long |
| Zdroj: |
ECS Transactions; April 2013, Vol. 45 Issue: 20 p65-73, 9p |
| Abstrakt: |
Photodynamic inactivation of pathogenic bacteria and cancer cells by novel water-soluble decacationic fullerene monoadducts, C60[>M(C3N6+C3)2] and C70[>M(C3N6+C3)2], were investigated. In the presence of a high number of electron-donating iodide anions as parts of quaternary ammonium salts in the arm region, we found that C70[>M(C3N6+C3)2] produced more highly reactive HO* radical than C60[>M(C3N6+C3)2], in addition to singlet oxygen (1O2). This finding offers an explanation of the preferential killing of Gram-positive and Gram-negative bacteria by C60[>M(C3N6+C3)2] and C70[>M(C3N6+C3)2], respectively. The hypothesis is that 1O2 can diffuse more easily into porous cell walls of Gram-positive bacteria to reach sensitive sites, while the less permeable Gram-negative bacterial cell wall needs the more reactive HO* to cause real damage. |
| Databáze: |
Supplemental Index |
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