| Autor: |
Ceccarini, M. Rachele, Tasegian, Anna, Franzago, Marica, Patria, F. Filomena, Albi, Elisabetta, Codini, Michela, Conte, Carmela, Bertelli, Matteo, Dalla Ragione, Laura, Stuppia, Liborio, Beccari, Tommaso |
| Zdroj: |
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics; April 2020, Vol. 183 Issue: 3 p155-163, 9p |
| Abstrakt: |
Evidence from family and twin studies points to a genetic contribution to the etiology of eating disorders (EDs), confirmed by the association of several single nucleotide polymorphisms (SNPs) with this group of disorders. Previous reports have suggested that the serotonin receptor (5‐HT2AR) and brain‐derived neurotrophic factor (BDNF) genes could be both involved in EDs susceptibility. In order to provide further evidence about such association, we focused our attention on two SNPs located in these genes carrying out a genetic association study on a large Italian cohort composed of 556 ED patients and 355 controls (CTRs). Obtained results confirm the presence of an association between 5‐HT2ARand BDNFgenes and the susceptibility to EDs. |
| Databáze: |
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