| Autor: |
Zinke, Michael, Kappes, Rudolf, Kindler, Klaus, Paulus Koschik, Anke, Goering, Uwe, Disselhoff, Johann, Soemantri, Peter, Grunert, Detlef, Laakmann, Karl Heinz, Gunasekaran, Ramakrishnan, Gartner, Britta, Marie Jacquet, Jeanne |
| Zdroj: |
Human Vaccines; September 2009, Vol. 5 Issue: 9 p592-598, 7p |
| Abstrakt: |
The combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio Haemophilus influenzaetype b (DTPa-HBV-IPV/Hib) vaccine produces similar hepatitis B responses as the HBV monovalent vaccine. Booster vaccination of immunocompetent individuals primed against hepatitis B in infancy is currently not recommended. We investigated persisting immunity to hepatitis B in 4-6 (Study A; 106745) and 7-9 (Study B; 106744) year-old children primed in infancy and boosted in the second year of life with DTPa-HBV-IPV/Hib. Immunity was assessed by measuring persisting anti-HBs antibodies and evaluating the response to a challenge dose of HBV vaccine. At 4-6 years of age 86.0% of 186 subjects had persisting anti-HBs ≥10mIU/ml increasing to 98.4% after the challenge. At 7-9 years of age, 78.0% of 186 subjects continued to have anti-HBs antibody concentrations ≥10mIU/ml, increasing to 98.9% after the challenge. In both studies anti-HBs antibody GMC rose >80-fold. An anamnestic response to the HBV challenge was observed in 95.7% and 98.9% of subjects in Studies A and B, respectively. In both studies, 87% of 38 subjects with initially undetectable circulating anti-HBs antibodies ( |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
