| Autor: |
Tuzun, Burcu Sumer, Fafal, Tugce, Tastan, Pelin, Kivcak, Bijen, Yelken, Besra Ozmen, Kayabasi, Cagla, Susluer, Sunde Yılmaz, Gunduz, Cumhur |
| Zdroj: |
Green Processing & Synthesis; December 2019, Vol. 9 Issue: 1 p153-163, 11p |
| Abstrakt: |
ASPwas used to synthesize FeNPA. They were characterized by UV-vis spectroscopy, FT-IR, TEM, SEM, XRD and ZP. The aim of this study was to evaluate in vitro cytotoxic activity and antioxidant acitivities of FeNPAand ASP. The antioxidant properties were evaluated using DPPH, ABTS+and H2O2assays. FeNPAhad higher antioxidant activity comparing to ASPaccording to DPPH (IC50: 3.48 μg/mL) and ABTS+(60.52%) assays. Anti-cancer activities of FeNPAand ASPwere investigated in breast cancer, melanoma and control cell lines. FeNPAwas more cytotoxic than ASPin MCF-7, MeWo, CHL-1, and HEL 299 cells. FeNPAhad shown that mitochondria induce apoptosis through stress in MDA-MB-231, and cells MeWo. ASPalso induced apoptosis 2.23-fold in MCF-7 cells. Progesterone receptor gene expression showed a 10-fold increase in a hormone-dependent MCF-7 cell line in ASP, and FeNPAtreatment. Expressions of BCL6, CXCL12, DNAJC15, RB1 and TPM1 in melanoma cancer cell lines were significantly increased in ASPand FeNPAadministration. It had been shown that FeNPAregulates gene expressions that may be considered important in terms of prognosis in breast cancer and melanoma cell lines and it is suggested that gene expressions regulated by FeNPAare also evaluated in animal models in vivo. |
| Databáze: |
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