| Autor: |
Diez, Ibai, Larson, Anna G., Nakhate, Vihang, Dunn, Erin C., Fricchione, Gregory L., Nicholson, Timothy R., Sepulcre, Jorge, Perez, David L. |
| Zdroj: |
Molecular Psychiatry; August 2021, Vol. 26 Issue: 8 p3817-3828, 12p |
| Abstrakt: |
Functional neurological (conversion) disorder (FND) is a neuropsychiatric condition whereby individuals present with sensorimotor symptoms incompatible with other neurological disorders. Early-life maltreatment (ELM) is a risk factor for developing FND, yet few studies have investigated brain network–trauma relationships in this population. In this neuroimaging–gene expression study, we used two graph theory approaches to elucidate ELM subtype effects on resting-state functional connectivity architecture in 30 patients with motor FND. Twenty-one individuals with comparable depression, anxiety, and ELM scores were used as psychiatric controls. Thereafter, we compared trauma endophenotypes in FND with regional differences in transcriptional gene expression as measured by the Allen Human Brain Atlas (AHBA). In FND patients only, we found that early-life physical abuse severity, and to a lesser extent physical neglect, correlated with corticolimbic weighted-degree functional connectivity. Connectivity profiles influenced by physical abuse occurred in limbic (amygdalar–hippocampal), paralimbic (cingulo-insular and ventromedial prefrontal), and cognitive control (ventrolateral prefrontal) areas, as well as in sensorimotor and visual cortices. These findings held adjusting for individual differences in depression/anxiety, PTSD, and motor phenotypes. In FND, physical abuse also correlated with amygdala and insula coupling to motor cortices. In exploratory analyses, physical abuse correlated connectivity maps overlapped with the AHBA spatial expression of three gene clusters: (i) neuronal morphogenesisand synaptic transmissiongenes in limbic/paralimbic areas; (ii) locomotory behaviorand neuronal generationgenes in left-lateralized structures; and (iii) nervous system developmentand cell motilitygenes in right-lateralized structures. These circuit-specific architectural profiles related to individual differences in childhood physical abuse burden advance our understanding of the pathophysiology of FND. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full text from SpringerLink