| Autor: |
Iwasaki, Keitaro, Iwasaki, Arihiro, Sumimoto, Shimpei, Matsubara, Teruhiko, Sato, Toshinori, Nozaki, Tomoyoshi, Saito-Nakano, Yumiko, Suenaga, Kiyotake |
| Zdroj: |
Journal of Natural Products; February 2020, Vol. 83 Issue: 2 p481-488, 8p |
| Abstrakt: |
An antimalarial lipopeptide, ikoamide, was isolated from an Okeaniasp. marine cyanobacterium. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral-phase HPLC analyses, spectroscopic analyses, and derivatization reactions. Ikoamide showed strong antimalarial activity with an IC50value of 0.14 μM without cytotoxicity against human cancer cell lines at 10 μM. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
