| Autor: |
Bista, Sudeep R., Lee, Sang Kyu, Thapa, Dinesh, Kang, Mi Jeong, Seo, Young Min, Kim, Ju Hyun, Kim, Dong Hyeon, Jahng, Yurngdong, Kim, Jung Ae, Jeong, Tae Cheon |
| Zdroj: |
Toxicological Research; September 2008, Vol. 24 Issue: 3 p195-199, 5p |
| Abstrakt: |
It has been reported that hepatic microsomal cytochrome P450 (CYP) 2E1 is responsible for the metabolism of chlorzoxazone (CZX) to 6-hydroxychlorzoxazone. The present study was undertaken to assess the possible interaction of rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, with CZX. Male Spraque-Dawley rats were administered with 80 mg/kg/day of oral rutaecarpine for three consecutive days. Twenty four hr after the pre-treatment with rutaecarpine, the rats were treated with 20 mg/kg of intravenous CZX Rat hepatic microsomes isolated from rutaecarpine-treated rats showed greater (50% increase) activity of p-nitrophenol hydroxylase (a marker of CYP2E1) when compared with the control rats. Compared with control rats, the AUC of CZX was significantly smaller (84% decrease) possibly due to significantly faster CL (646% increase) in rats pretreated with rutaecarpine. This could be, at least partially, due to induction of CYP2E1 by rutaecarpine. |
| Databáze: |
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