| Autor: |
Ekweogu, Celestine Nwabu, Ude, Victor Chibueze, Nwankpa, Promise, Emmanuel, Okezie, Ugbogu, Eziuche Amadike |
| Zdroj: |
Toxicological Research; 20240101, Issue: Preprints p1-12, 12p |
| Abstrakt: |
Solanum aethiopicumis used in ethnomedicine for the treatment of overweight, constipation and anaemia. This study evaluated the ameliorative effect of aqueous leaf extract of S. aethiopicumon phenylhydrazine-induced anaemia in rats. Acute toxicity was determined in male and female rats (n?=?5/group/sex) by oral administration of single dose of up to 5000 mg/kg of the S. aethiopicumextract. The experimental rats were randomly grouped into five (5) groups of 6 rats each. Group (i) served as normal control, group (ii) negative control, group (iii) standard drug-5 mg/kg ferrous sulphate, groups (iv) and (v), 200 and 400 mg/kg of S. aethiopicumextract respectively. Phenylhydrazine (PHZ) was administered intraperitoneally at the dose of 50 mg/kg body weight for two consecutive days to groups (ii–v). After 14 days, the rats were sacrificed; blood, liver and kidney were collected. The haematological, lipid profile, liver and kidney function parameters were determined and the histopathology of the liver and kidney were examined. In acute toxicity study, no signs of toxicity or death were recorded. The study shows an observable significant (P?
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| Databáze: |
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