| Autor: |
Dai, Tianyuan, Zhang, Hui, Liu, Xinguo, Dai, Zhongying, He, Pengbo, Ma, Yuanyuan, Shen, Guosheng, Chen, Weiqiang, Li, Qiang |
| Zdroj: |
Physical & Engineering Science in Medicine; 20240101, Issue: Preprints p1-8, 8p |
| Abstrakt: |
With the extension of ion species in ion-beam radiotherapy, the sole dependence of relative biological effectiveness (RBE) on linear energy transfer (LET) is insufficient when comparing RBE for ion beams with the same LET value. The aim of the present study was to provide a systematic study of the nanodosimetry for ion beams with the same LET value. Based on the calculated LET profiles of ion beams with range about 130 mm, lineal energy spectra and dose-averaged lineal energy yDon 4 nm site for various clinical ion beams were obtained. Then, the lineal energy spectra and yDvalues were compared for ion beams with the same LET values. The results showed that the relationships between yDand LET for various ion beams present an dependence on ion species. For ion beams with the same LET value, the ion beams with smaller nucleon number yielded greater yDvalues. The probability of the small-nucleon-number ion beams to generate large energy deposition events on nanoscale was higher than that of the large-nucleon-number ion beams. The dependence of the relationship between RBE and LET on ion species might be attributed to the fluctuation of energy depositions on nanometer scale. |
| Databáze: |
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