AGGLUTININ RESPONSES TO S. TYPHI H ANTIGEN IN INTACT AND SUBLETHALLY IRRADIATED MICE FOLLOWING THE INTRAPERITONEAL INJECTION OF HOMOLOGOUS SPLEEN CELL SUSPENSIONS

Autor:	Bain, Gordon O.
Zdroj:	Canadian Journal of Physiology and Pharmacology; July 1960, Vol. 38 Issue: 7 p621-626, 6p
Abstrakt:	Agglutinin production was depressed in unirradiated mice challenged with Salmonella typhiH antigen after intraperitoneal transfer of spleen cells from immunized or non-immunized homologous donors. The inhibition of agglutinin production in the homologous situation and the production of agglutinins by mouse tissues appear to be separate immunological phenomena differing in radiosensitivity. This conclusion is based on the observations that the inhibitory effect was abolished by 500-r but not by 200- or 400-r whole-body irradiation of the recipients before spleen cell transfer, and agglutinin production was depressed more by 400 r plus homologous cell transfer than by the latter procedure alone. Thus, radiation doses of 400 r contributed to depression of antibody production without demonstrably lessening the inhibitory effect attributed to the homologous state.
Databáze:	Supplemental Index
Externí odkaz:	Zobrazit plný text záznamu