| Autor: |
Chaudhari, Sanjay R., Patil, Pramod N., Patil, Ulhas K., Patel, Harun M., Rajput, Jamatsing D., Pawar, Nilesh S., Patil, Dipak B. |
| Zdroj: |
Chemical Data Collections; February 2020, Vol. 25 Issue: 1 |
| Abstrakt: |
The current investigation describes the synthesis of N-substituted phenyl acetamide benzimidazole based derivatives 3(a-f)and their systematic analysis against Methicillin Resistant Staphylococcus aureus(MRSA). These compounds were characterized by IR, 1H NMR, 13C NMR spectrometry, elemental analysis and Mass. The derivative 2-(1H-benzimidazol-1-yl)-N-(3-nitrophenyl) acetamide (3f) exhibited significant potent antibacterial activity (6 fold more potent as compared to the standard drug Sultamicillin) against the MRSA (ATCC 4330). The structural correlationship indicates that m-nitro phenyl at N-position of benzimidazole strongly favours the anti-MRSA activity compared to the p-nitro phenyl. |
| Databáze: |
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