The use of methylprednisolone during cardiopulmonary bypass

Autor: Dietzman, Ronald H., Lunseth, John B., Goott, Bernard, Bergcr, Edward C.
Zdroj: Journal of Thoracic and Cardiovascular Surgery; June 1975, Vol. 69 Issue: 6 p870-873, 4p
Abstrakt: A study was designed to evaluate the hemodynamic effects of massive doses of methylprednisolone (30 mg. per kilogram) during cardiopulmonary bypass at normothermia and hypothermia. In 427 patients studied, significantly less vasoconstriction (p < 0.01) and improved perfusion flows (p < 0.0005) were obtained at comparable pressure levels in the steroid-treated group (272 patients) compared with the control group (155 patients). Because of these measured parameters, methylprednisolone should be considered a valuable adjunct to improving tissue perfusion during cardiopulmonary bypass.
Databáze: Supplemental Index