Regioselective F-18 radiolabeling of AM694, a CB1 cannabinoid receptor ligand

Autor:	Willis, Peter G., Katoch-Rouse, Reeti, Horti, Andrew G.
Zdroj:	Journal of Labelled Compounds and Radiopharmaceuticals; August 2003, Vol. 46 Issue: 9 p799-804, 6p
Abstrakt:	[18F]AM694, [1-(5-[18F]fluoropentyl)-1H-indol-3-yl]-(2-iodophenyl)methanone, 1b, a potential radiotracer for imaging of cerebral cannabinoid receptor (CB1), has been synthesized by no-carrier-added regioselective radiofluorination of the corresponding tosylate. [18F]AM694 was obtained in 20% radiochemical yield (non-decay-corrected) with a specific activity of 14 500 mCi/µmol, a radiochemical purity of > 99%, and a chemical purity of 95.5%. Copyright © 2003 John Wiley & Sons, Ltd.
Databáze:	Supplemental Index
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