| Autor: |
Rosenkranz, Eliot R., Okamoto, Fumiyuki, Buckberg, Gerald D., Vinten-Johansen, Jakob, Robertson, John M., Bugyi, Helen |
| Zdroj: |
Journal of Thoracic and Cardiovascular Surgery; September 1984, Vol. 88 Issue: 3 p402-410, 9p |
| Abstrakt: |
Cold blood cardioplegic techniques are limited in their ability to protect energy-depleted hearts during aortic clamping. This study extends our previous observations on the benefits of amino acid (l-ghitamate) enrichment of blood cardioplegic solutions as well as the added metabolic benefits of normothermic induction of cardioplegic arrest to increase the rate of repair of energy-depleted hearts. The results demonstrate that l-glutamate enrichment of blood cardioplegic solutions significantly improves metabolic recovery (greater oxygen consumption, better anaerobic metabolism) and ventricular performance. Normothermic induction of glutamate-enriched cardioplegia allowed complete recovery of myocardial metabolism and function compared to cold blood cardioplegic technique and may be used as a form of “active resuscitation” of energy-depleted hearts. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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