| Autor: |
Nafis, Ahmed, Kasrati, Ayoub, Jamali, Chaima Alaoui, Samri, Salah Eddine, Mezrioui, Noureddine, Abbad, Abdelaziz, Hassani, Lahcen |
| Zdroj: |
Journal of Essential Oil Bearing Plants; September 2019, Vol. 22 Issue: 5 p1289-1298, 10p |
| Abstrakt: |
AbstractFicus caricais one of the oldest and earliest cultivated fruits in the world. To our knowledge, little information is available on the antimicrobial and antioxidant activities of F. caricaleaf essential oil (EO). Also, the potential synergistic interaction of this EO with standard antibiotics against multidrug resistant bacteria and clinically pathogenic yeasts has not been investigated. The characterization of the EO with GC/MS analyses led to identification of 35 components, representing 98.1 % of the total oil, with ficusin (32.8 %), caryophyllene oxide (9.0 %), bergapten (6.1 %) as major constituents. Regarding the antioxidant property, F. caricaleaf EO showed moderate activity, as measured by DPPH free radical scavenging (1.45 ± 0.05 mg/mL), β-carotene/linoleic acid (1.56 ± 0.09 mg/mL) and reducing power assays (1.92 ± 0.13 mg/mL). The antimicrobial tests showed that EO presented higher activity against all tested microorganisms with MIC values ranging from 4.75 mg/mL to 38 mg/mL. The combination between conventional antibiotics and EO showed a high synergistic effect, especially against the Gram-positive bacteria, with FICI values ranged from 0.312 to 0.750. Interestingly, F. caricaleaf oil has strongly reduced the known antibiotic MICs by 1 to 16-fold. |
| Databáze: |
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