| Autor: |
Buonfiglioli, Alice, Efe, Ibrahim E., Guneykaya, Dilansu, Ivanov, Andranik, Huang, Yimin, Orlowski, Elisabeth, Krüger, Christina, Deisz, Rudolf A., Markovic, Darko, Flüh, Charlotte, Newman, Andrew G., Schneider, Ulf C., Beule, Dieter, Wolf, Susanne A., Dzaye, Omar, Gutmann, David H., Semtner, Marcus, Kettenmann, Helmut, Lehnardt, Seija |
| Zdroj: |
Cell Reports; December 2019, Vol. 29 Issue: 11 p3460-3471.e7 |
| Abstrakt: |
Microglia express Toll-like receptors (TLRs) that sense pathogen- and host-derived factors, including single-stranded RNA. In the brain, let-7microRNA (miRNA) family members are abundantly expressed, and some have recently been shown to serve as TLR7 ligands. We investigated whether let-7miRNA family members differentially control microglia biology in health and disease. We found that a subset of let-7miRNA family members function as signaling molecules to induce microglial release of inflammatory cytokines, modulate antigen presentation, and attenuate cell migration in a TLR7-dependent manner. The capability of the let-7miRNAs to control microglial function is sequence specific, mapping to a let-7UUGU motif. In human and murine glioblastoma/glioma, let-7miRNAs are differentially expressed and reduce murine GL261 glioma growth in the same sequence-specific fashion through microglial TLR7. Taken together, these data establish let-7miRNAs as key TLR7 signaling activators that serve to regulate the diverse functions of microglia in health and glioma. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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