| Autor: |
Singh, J., Kronenthal, D. R., Schwinden, M., Godfrey, J. D., Fox, R., Vawter, E. J., Zhang, B., Kissick, T. P., Patel, B., Mneimne, O., Humora, M., Papaioannou, C. G., Szymanski, W., Wong, M. K. Y., Chen, C. K., Heikes, J. E., DiMarco, J. D., Qiu, J., Deshpande, R. P., Gougoutas, J. Z., Mueller, R. H. |
| Zdroj: |
Organic Letters; August 2003, Vol. 5 Issue: 17 p3155-3158, 4p |
| Abstrakt: |
An efficient asymmetric synthesis of the vasopeptidase inhibitor BMS-189921 was accomplished. Two short enantioselective syntheses of the common key intermediate (S)-α-aminoazepinone 6b were developed. Olefin 3 was converted to 6b via asymmetric hydrogenation. Alternatively, enyne 12 was converted to racemic α-aminoazepinone 15b, which was transformed to 6b by a practical dynamic resolution. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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