Agenesis of corpus callosum: prenatal diagnosis and prognosis

Autor: Moutard, Marie-Laure, Kieffer, Virginie, Feingold, Josué, Kieffer, François, Lewin, Fanny, Adamsbaum, Catherine, Gélot, Antoinette, Plana, Jaume Campistol i, Bogaert, Patrick van, André, Monique, Ponsot, Gérard
Zdroj: Child's Nervous System; August 2003, Vol. 19 Issue: 7-8 p471-476, 6p
Abstrakt: IntroductionAgenesis of corpus callosum (ACC) is commonly diagnosed prenatally. When isolated, it appears to carry a good prognosis but studies are often retrospective and follow-up short. We report a prospective study of 17 children (11 boys, 6 girls) with prenatally diagnosed isolated ACC.MethodsNeuropsychological evaluation was performed each year and results at the ages of 2, 4, and 6 years were compared.ResultsFebrile seizures occurred in 3 patients. Median intellectual quotient (IQ) was within the normal range (80–109) and nonrelated to partial or complete ACC, sex, or febrile seizures. Lower median IQ was significantly related to low cultural status. With age, the number of children with IQ in the lower range (80–89) increased and slowness, attentional troubles, and instability appeared.ConclusionThis study demonstrates that if outcome of isolated ACC is favorable, a long follow-up is necessary: with age, IQ in the lower range and behavioral troubles are linked to difficulties in school.
Databáze: Supplemental Index