| Autor: |
Hamada, Yoriomi, Yamamoto, Takeshi, Nakamura, Yoshihide, Sufu-Shimizu, Yoko, Nanno, Takuma, Fukuda, Masakazu, Ono, Makoto, Oda, Tesuro, Okuda, Shinichi, Ueyama, Takeshi, Kobayashi, Shigeki, Yano, Masafumi |
| Zdroj: |
Biochemistry and Biophysics Reports; March 2020, Vol. 21 Issue: 1 |
| Abstrakt: |
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart disease that causes heart failure and/or sudden cardiac death. Several desmosomal genes (DSC2, PKG, PKP2, DSP, and RyR2) are thought to be the causative gene involved in ARVC. Out of them, DSC2 mutations account for 2% of ARVC genetic abnormalities. This study aimed to clarify the effect of G790del mutation in DSC2 on the arrhythmogenic mechanism and cardiac function in a mouse model. |
| Databáze: |
Supplemental Index |
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