Durvalumab plus platinum–etoposide versus platinum–etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial

Autor: Paz-Ares, Luis, Dvorkin, Mikhail, Chen, Yuanbin, Reinmuth, Niels, Hotta, Katsuyuki, Trukhin, Dmytro, Statsenko, Galina, Hochmair, Maximilian J, Özgüroğlu, Mustafa, Ji, Jun Ho, Voitko, Oleksandr, Poltoratskiy, Artem, Ponce, Santiago, Verderame, Francesco, Havel, Libor, Bondarenko, Igor, Kazarnowicz, Andrzej, Losonczy, György, Conev, Nikolay V, Armstrong, Jon, Byrne, Natalie, Shire, Norah, Jiang, Haiyi, Goldman, Jonathan W, Batagelj, Emilio, Casarini, Ignacio, Pastor, Anea Viviana, Sena, Susana Noemi, Zarba, Juan Jose, Burghuber, Otto, Hartl, Sylvia, Hochmair, Maximilian J, Lamprecht, Bernd, Studnicka, Michael, Alberto Schlittler, Luis, Augusto Martinelli de Oliveira, Fabricio, Calabrich, Aknar, Colagiovanni Girotto, Gustavo, Dos Reis, Peo, Fausto Nino Gorini, Carlos, Rafael Martins De Marchi, Peo, Serodio da Rocha Baldotto, Clarissa, Sette, Claudia, Zukin, Mauro, Conev, Nikolay V, Dudov, Assen, Ilieva, Rumyana, Koynov, Krassimir, Krasteva, Rositsa, Tonev, Ivan, Valev, Spartak, Venkova, Violetka, Bi, Minghong, Chen, Chengshui, Chen, Yuan, Chen, Zhendong, Fang, Jian, Feng, Jifeng, Han, Zhigang, Hu, Jie, Hu, Yi, Li, Wei, Liang, Zongan, Lin, Zhong, Ma, Rui, Ma, Shenglin, Nan, Kejun, Shu, Yongqian, Wang, Kai, Wang, Mengzhao, Wu, Gang, Yang, Nong, Yang, Zhixiong, Zhang, Helong, Zhang, Wei, Zhao, Jun, Zhao, Yanqiu, Zhou, Caicun, Zhou, Jianying, Zhou, Xiangdong, Havel, Libor, Kolek, Vitezslav, Koubkova, Leona, Roubec, Jaromir, Skrickova, Jana, Zemanova, Milada, Chouaid, Christos, Hilgers, Werner, Lena, Hervé, Moro-Sibilot, Denis, Robinet, Gilles, Souquet, Pierre-Jean, Alt, Jürgen, Bischoff, Helge, Grohe, Christian, Laack, Eckart, Lang, Susanne, Panse, Jens, Reinmuth, Niels, Schulz, Christian, Bogos, Krisztina, Csánky, Eszter, Fülöp, Anea, Horváth, Zsolt, Kósa, Judit, Laczó, Ibolya, Losonczy, György, Pajkos, Gábor, Pápai, Zsuzsanna, Pápai Székely, Zsolt, Sárosi, Veronika, Somfay, Attila, Somogyiné Ezer, Éva, Telekes, Anás, Bar, Jair, Gottfried, Maya, Heching, Norman Isaac, Zer Kuch, Alona, Bartolucci, Roberta, Bettini, Anna Cecilia, Delmonte, Angelo, Garassino, Marina Chiara, Minelli, Mauro, Roila, Fausto, Verderame, Francesco, Atagi, Shinji, Azuma, Koichi, Goto, Hisatsugu, Goto, Koichi, Hara, Yu, Hayashi, Hidetoshi, Hida, Toyoaki, Hotta, Katsuyuki, Kanazawa, Kenya, Kanda, Shintaro, Kim, Young Hak, Kuyama, Shoichi, Maeda, Tadashi, Morise, Masahiro, Nakahara, Yasuharu, Nishio, Makoto, Nogami, Naoyuki, Okamoto, Isamu, Saito, Haruhiro, Shinoda, Masahiro, Umemura, Shigeki, Yoshida, Tatsuya, Claessens, Niels, Cornelissen, Robin, Heniks, Lizza, Hiltermann, Jeroen, Smit, Egbert, Staal van den Brekel, Agnes, Kazarnowicz, Andrzej, Kowalski, Dariusz, Mańdziuk, Slawomir, Mróz, Robert, Wojtukiewicz, Marek, Ciuleanu, Tudor, Ganea, Doina, Ungureanu, Anei, Dvorkin, Mikhail, Luft, Alexander, Moiseenko, Vladimir, Poltoratskiy, Artem, Sakaeva, Dina, Smolin, Alexey, Statsenko, Galina, Vasilyev, Alexander, Vladimirova, Lyubov, Anasina, Igor, Chovanec, Jozef, Demo, Pavol, Godal, Robert, Kasan, Peter, Stresko, Marian, Urda, Michal, Cho, Eun Kyung, Ji, Jun Ho, Kim, Joo-Hang, Kim, Sang-We, Lee, Gyeong-Won, Lee, Jong-Seok, Lee, Ki Hyeong, Lee, Kyung Hee, Lee, Yun Gyoo, Amelia Insa Molla, Maria, Domine Gomez, Manuel, Ignacio Delgado Mingorance, Juan, Isla Casado, Dolores, Lopez Brea, Marta, Majem Tarruella, Margarita, Morán Bueno, Teresa, Navarro Mendivil, Alejano, Paz-Ares Rodríguez, Luis, Ponce Aix, Santiago, Rosario Garcia Campelo, Maria, Chang, Gee-Chen, Chen, Yen-Hsun, Chiu, Chao-Hua, Hsia, Te-Chun, Lee, Kang-Yun, Li, Chien-Te, Wang, Chin-Chou, Wei, Yu-Feng, Wu, Shang-Yin, Alacacıoğlu, Ahmet, Çiçin, Irfan, Demirkazik, Ahmet, Erman, Mustafa, Göksel, Tuncay, Özgüroğlu, Mustafa, Adamchuk, Hryhoriy, Bondarenko, Igor, Kolesnik, Oleksii, Kryzhanivska, Anna, Ostapenko, Yuriv, Shevnia, Serhii, Shparyk, Yaroslav, Trukhin, Dmytro, Ursol, Grygorii, Voitko, Nataliia, Voitko, Oleksandr, Vynnychenko, Ihor, Babu, Sunil, Chen, Yuanbin, Chiang, Anne, Chua, Winston, Dakhil, Shaker, Dowlati, Afshin, Goldman, Jonathan W, Haque, Basir, Jamil, Rodney, Knoble, Jeanna, Lakhanpal, Shailena, Mi, Kailhong, Nikolinakos, Petros, Powell, Steven, Ross, Helen, Schaefer, Eric, Schneider, Jeffrey, Spahr, Joseph, Spigel, David, Stilwill, Joseph, Sumey, Christopher, Williamson, Michael
Zdroj: The Lancet; November 2019, Vol. 394 Issue: 10212 p1929-1939, 11p
Abstrakt: Most patients with small-cell lung cancer (SCLC) have extensive-stage disease at presentation, and prognosis remains poor. Recently, immunotherapy has demonstrated clinical activity in extensive-stage SCLC (ES-SCLC). The CASPIAN trial assessed durvalumab, with or without tremelimumab, in combination with etoposide plus either cisplatin or carboplatin (platinum–etoposide) in treatment-naive patients with ES-SCLC.
Databáze: Supplemental Index