In vitrosynergy of echinocandins with triazoles against fluconazole-resistant Candida parapsilosiscomplex isolates

Autor: Ahmadi, Ali, Mahmoudi, Shahram, Rezaie, Sassan, Hashemi, Sayed Jamal, Dannaoui, Eric, Badali, Hamid, Ghaffari, Mansoureh, Aala, Farzad, Izadi, Alireza, Maleki, Aida, Meis, Jacques F., Khodavaisy, Sadegh
Zdroj: Journal of Global Antimicrobial Resistance; June 2020, Vol. 21 Issue: 1 p331-334, 4p
Abstrakt: •The distribution of 15 fluconazole-resistant clinical isolates of Candida parapsilosiscomplex were as follows: Candida parapsilosis sensu stricto(n = 7), C. orthopsilosis(n = 5) and C. metapsilosis(n = 3).•In vitro combinations of fluconazole with anidulafungin (fractional inhibitory concentration index, FICI 0.07–0.37), fluconazole with micafungin (FICI 0.25–0.5), itraconazole with anidulafungin (FICI 0.15–0.37) and itraconazole with micafungin (FICI 0.09–0.37) were synergistic.•The combination of fluconazole and itraconazole with either anidulafungin or micafungin demonstrated synergistic interactions against C. parapsilosisspecies complex, especially against isolates with elevated MIC values.
Databáze: Supplemental Index
Externí odkaz: