| Autor: |
Johnson, J. G., Black, W. D., Vukovich, R. A., Hatch, F. E., Friedman, B. I., Blackwell, C. F., Shenouda, A. N., Share, L., Shade, R. E., Acchiardo, S. R., Muirhead, E. E. |
| Zdroj: |
Clinical Science; January 1975, Vol. 48 Issue: Supplement 2 p53s-56s, 4p |
| Abstrakt: |
1. The results of the administration of the nonapeptide inhibitor (SQ 20,881) of the enzymatic conversion of angiotensin I into angiotensin II in twelve severe hypertensive patients are presented. 2. Administration of the compound was associated with a fall in blood pressure in ten of twelve patients. 3. Four patients had a normal plasma renin activity (PRA) with a range of 1.6–3.7 ng h-1 ml-1 and eight patients had a high PRA with a range of 5.0–74 ng h-1 ml-1. Two of the patients with normal PRA had no fall in blood pressure despite receiving 2 mg/kg of the compound. Two patients with normal PRA, however, did respond, thus indicating that a high PRA is not necessary for a response to the inhibitor compound. 4. It was found that haemodialysis or diuresis with frusemide enhanced the blood pressure response to the compound. 5. The presence of a measured low total blood volume was found to be associated with an exaggerated fall in blood pressure to a small dose of compound (0.125 mg/kg) in one patient. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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