| Autor: |
Shainkin-Kestenbaum, Ruth, Adler, Andrew J., Berlyne, Geoffrey M., Caruso, C. |
| Zdroj: |
Clinical Science; November 1989, Vol. 77 Issue: 5 p463-466, 4p |
| Abstrakt: |
1. The effect of Al3+ on superoxide dismutase in vitro was studied, since in uraemia there is excessive superoxide production and frequently an elevated serum Al3+ level. Thus, the protective role of superoxide dismutase is particularly important. 2. Al3+ in concentrations similar to those found in the serum of uraemic patients inhibits superoxide dismutase activity. The degree of inhibition is directly proportional to the Al3+ level. 3. The combination of excessive oxygen free radical production with an increased Al3+ level may contribute to a variety of complications, including aluminium dementia or initiation and promotion of carcinogenic processes, which are known to be more common in uraemic patients. |
| Databáze: |
Supplemental Index |
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