| Autor: |
Casson, I. F., Clayden, D. A., Cope, G. F., Lee, M. R. |
| Zdroj: |
Clinical Science; August 1983, Vol. 65 Issue: 2 p159-164, 6p |
| Abstrakt: |
1. γ-Glutamyl l-dopa, a renal pro-drug for dopamine, was administered to rats before and after injection of glycerol, and to a control group which received water in place of glycerol. A third group of rats was given glycerol but no γ-glutamyl l-dopa. 2. The plasma creatinine in rats given γ-glutamyl l-dopa and glycerol was significantly lower than in rats receiving glycerol alone. 3. The fall in urine creatinine excretion, and polyuria, after glycerol was reduced by γ-glutamyl l-dopa and the natriuresis abolished. 4. γ-Glutamyl l-dopa given alone caused a 4000-fold increase in urine dopamine excretion, associated with a natriuresis. 5. The administration of γ-glutamyl l-dopa reduces the severity of renal failure produced by glycerol. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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