| Autor: |
Rees, Robert C., Parker, Simon, Platts, Andrew, Blackburn, Michael G., MacNeil, Sheila |
| Zdroj: |
Bioscience Reports; October 1987, Vol. 7 Issue: 10 p771-775, 5p |
| Abstrakt: |
The calmodulin antagonist W7 and 4 of its analogues were examined for their ability to inhibit human NK cell mediated cytotoxicity. With the exception of one of these compounds, which is extremely hydrophobic, there was a good correlation between the ability of drugs to inhibit human NK antitumour cytotoxicity and calmodulin-dependent phosphodiesterase activity in vitro. The most potent of the compounds, 5-iodo-l-C8, an analogue of W7, has an IC50 of 3 μM upon biological and biochemical assay. This particular compound is both more potent and specific than the parent compound W7, is non-toxic to cells over the range used and is also capable of inhibiting the biological activity of NK cells upon pre-treatment of the effector cells, inferring the mechanism of NK cytotoxicity to be calmodulin dependent. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full text from SpringerLink