| Autor: |
Taylor, R G, Beveridge, D J, Fuller, P J |
| Zdroj: |
Biochemical Journal; September 1992, Vol. 286 Issue: 3 p737-741, 5p |
| Abstrakt: |
Massive small-bowel resection results in a marked adaptive response in the residual terminal ileum. Increased polyamine synthesis is a necessary component of this response. The ileal L-cell-derived peptides enteroglucagon and peptide tyrosine tyrosine (PYY) have been implicated as humoral mediators of this response. We have previously reported a rapid and sustained increase in glucagon mRNA concentrations after massive small-bowel resection. In this study using an inhibitor of the rate-limiting enzyme in polyamine biosynthesis, ornithine decarboxylase, we have demonstrated that the response of the glucagon and PYY genes to massive small-bowel resection is dependent on polyamine biosynthesis. In addition, we have examined the response of both the ornithine decarboxylase and c-jun genes in this model of intestinal adaptation. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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