| Autor: |
Cairo, G, Tacchini, L, Schiaffonati, L, Rappocciolo, E, Ventura, E, Pietrangelo, A |
| Zdroj: |
Biochemical Journal; December 1989, Vol. 264 Issue: 3 p925-928, 4p |
| Abstrakt: |
In rats with chronic dietary iron overload, a higher amount of liver ferritin L-subunit mRNA was found mainly engaged on polysomes, whereas in control rats ferritin L-subunit mRNA molecules were largely stored in ribonucleoprotein particles. On the other hand, ferritin H-subunit mRNA was unchanged by chronic iron load and remained in the inactive cytoplasmic pool. In agreement with previous reports, in rats acutely treated with parenteral iron, only the ferritin L-subunit mRNA increased in amount, whereas both ferritin subunit mRNAs shifted to polysomes. This may indicate that, whereas in acute iron overload the hepatocyte operates a translation shift of both ferritin mRNAs to confront rapidly the abrupt entry of iron into the cell, during chronic iron overload it responds to the slow iron influx by translating a greater amount of L-subunit mRNA to synthesize isoferritins more suitable for long-term iron storage. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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