| Autor: |
De Meester, F, Joris, B, Lenzini, M V, Dehottay, P, Erpicium, T, Dusart, J, Klein, D, Ghuysen, J M, Frère, J M, Van Beeumen, J |
| Zdroj: |
Biochemical Journal; June 1987, Vol. 244 Issue: 2 p427-432, 6p |
| Abstrakt: |
The active-site serine of the extracellular beta-lactamases of Streptomyces cacaoi and Streptomyces albus G has been labelled with beta-iodopenicillanate. The determination of the sequence of the labelled peptides obtained after trypsin digestion of the denatured proteins indicate both enzymes to be class A beta-lactamases. Surprisingly the two Streptomyces enzymes do not appear to be especially homologous, and none of them exhibited a high degree of homology with the Streptomyces R61 DD-peptidase. Our data confirm that, as a family of homologous enzymes, class A is rather heterogeneous, with only a small number of conserved residues in all members of the class. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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