| Autor: |
Andrews, H E, Aitken, J W, Hassall, D G, Skinner, V O, Bruckdorfer, K R |
| Zdroj: |
Biochemical Journal; March 1987, Vol. 242 Issue: 2 p559-564, 6p |
| Abstrakt: |
Low-density lipoproteins (LDL) have been shown to cause aggregation of human blood platelets at concentrations above 2 g of protein/l. The secretion of the contents of platelet dense granules was detected, but not that of the lysosomes. LDL gave rise to a mobilization of [3H]arachidonic acid from phospholipids and the appearance of products of the cyclo-oxygenase pathway after only 10 s. LDL-promoted aggregation was inhibited by both aspirin and indomethacin. There was an increase in 3H-labelled diacylglycerols and the phosphorylation of 47 kDa proteins. LDL therefore shares at least some of the mechanisms of stimulus/response coupling with those of other agonists. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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