| Autor: |
Michell, Robert H., Jones, Lynne M. |
| Zdroj: |
Biochemical Journal; January 1974, Vol. 138 Issue: 1 p47-52, 6p |
| Abstrakt: |
1. Adrenergic agonists provoke a marked increase in labelling of phosphatidylinositol in fragments of rat parotid gland. 2. Adrenaline and phenylephrine (an adrenergic a-agonist) are effective stimulants, but isoprenaline (an adrenergic ß-agonist) is relatively ineffective. 3. The response evoked by phenylephrine or adrenaline is prevented by prior incubation of the tissue with phenoxybenzamine (an a-receptor blocking agent), but not by prior incubation with pindolol (a ß-receptor blocking agent). 4. Adrenergic stimulation of phosphatidylinositol metabolism in parotid gland is therefore mediated through a-receptors, in common with the adrenaline-induced K+ efflux. It is not linked to enzyme secretion, which is triggered by stimulation of ß-receptors. 5. It is suggested that the stimulation of phospholipid metabolism that occurs in several other tissues in the presence of adrenaline or noradrenaline may also involve a-receptors. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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