| Autor: |
Lichtenstein, A V, Shapot, V S |
| Zdroj: |
Biochemical Journal; December 1976, Vol. 159 Issue: 3 p783-794, 12p |
| Abstrakt: |
A model of cytoplasm-governed transcription is presented. The nuclear membrane has a selective permeability towards nuclear pre-mRNA molecules which are provided with group-specific non-translated “passwords”. RNA transcription on the chromatin proceeds under a dual control. One of them is gene regulation according to the Britten-Davidson and Georgiev models. The other is cytoplasm-governed regulation mediated through the selective transport of mRNA from nucleus to cytoplasm. Pre-mRNA molecules which are not “in immediate demand” by the cytoplasm and therefore accumulating the nucleus repress their own synthesis by end-product inhibition. The interrelationship of the two types of regulation in the course of cell development is discussed. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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