Molecular evidence for the role of a ferric reductase in iron transport

Autor: McKie, A. T., Latunde-Dada, G. O., Miret, S., McGregor, J. A., Anderson, G. J., Vulpe, C. D., Wrigglesworth, J. M., Simpson, R. J.
Zdroj: Biochemical Society Transactions; August 2002, Vol. 30 Issue: 4 p722-724, 3p
Abstrakt: Duodenal cytochrome b (Dcytb) is a haem protein similar to the cytochrome b561 protein family. Dcytb is highly expressed in duodenal brush-border membrane and is implicated in dietary iron absorption by reducing dietary ferric iron to the ferrous form for transport via Nramp2/DCT1 (divalent-cation transporter 1)/DMT1 (divalent metal-transporter 1). The protein is expressed in other tissues and may account for ferric reductase activity at other sites in the body.
Databáze: Supplemental Index