Increased Global DNA Hypomethylation in Distant Metastatic and Dedifferentiated Thyroid Cancer.

Autor: Klein Hesselink, Esther N, Zafon, Carles, Villalmanzo, Núria, Iglesias, Carmela, van Hemel, Bettien M, Klein Hesselink, Mariëlle S, Montero-Conde, Cristina, Buj, Raquel, Mauricio, Dídac, Peinado, Miguel A, Puig-Domingo, Manel, Riesco-Eizaguirre, Garcilaso, Reverter, Jordi L, Robledo, Mercedes, Links, Thera P, Jordà, Mireia
Zdroj: The Journal of Clinical Endocrinology & Metabolism; February 2018, Vol. 103 Issue: 2 p397-406, 10p
Abstrakt: Global DNA hypomethylation is a major event for the development and progression of cancer, although the significance in thyroid cancer remains unclear. Therefore, we aimed to investigate its role in thyroid cancer progression and its potential as a prognostic marker.
Databáze: Supplemental Index