Pazopanib-Induced Liver Toxicity in Patients With Metastatic Renal Cell Carcinoma: Effect of UGT1A1Polymorphism on Pazopanib Dose Reduction, Safety, and Patient Outcomes

Autor:	Henriksen, Jakob N., Bøttger, Pernille, Hermansen, Carina K., Ladefoged, Søren A., Nissen, Peter H., Hamilton-Dutoit, Stephen, Fink, Thomas L., Donskov, Frede
Zdroj:	Clinical Genitourinary Cancer; February 2020, Vol. 18 Issue: 1 p62-68.e2
Abstrakt:	Pazopanib can induce liver toxicity in patients with metastatic renal cell carcinoma (mRCC). We assessed the effect of a TA repeat polymorphism in the UGT1A1(uridine diphosphate glucuronosyltransferase 1A1) gene encoding uridine diphosphate glucuronosyltransferase 1A1 on liver toxicity, dose reductions, and patient outcomes.
Databáze:	Supplemental Index
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