| Autor: |
Geller, Barbara, Cooper, Thomas B., Watts, Hazel E., Cosby, Carolyn M., Fox, Louis W. |
| Zdroj: |
Progress in Neuro-Psychopharmacology and Biological Psychiatry; May 1992, Vol. 16 Issue: 3 p281-299, 19p |
| Abstrakt: |
1.1. This manuscript reports the early findings from a National Institute on Drug Abuse funded study of lithium for adolescents dually diagnosed with bipolar and substance dependency disorders. The authors elected to publish early findings in the hope that it would accomplish a twofold mission.2.2. The first part would be to encourage other investigators to participate in research in this area and the second would be to heighten the awareness of clinicians that adolescents presenting with either one of these disorders might also have the other.3.3. The early findings demonstrated the feasibility of recruiting, retaining and monitoring this complex population on an outpatient basis.4.4. Steady-state serum lithium levels were pharmacokinetically placed in the study range, 0.9–1.3 mEq/L. Preliminary results are encouraging in finding lithium more effective than placebo for alleviating both the substance dependency and the mood disordered symptomatology.5.5. The characteristics of the study population to date have been chronicity of both disorders, impairment in the severe range in multiple areas of functioning, and strong family histories for both affective and substance use disorders. The substance dependency was to both alcohol and marijuana; but all subjects also had marked polydrug abuse.6.6. In order to best monitor lithium compliance and drug/alcohol use during protocol, randomly timed weekly serum and urine assays were obtained.7.7. The implications of these early findings for the outcome of this acute phase study and for the development of longitudinal treatment strategies are discussed. |
| Databáze: |
Supplemental Index |
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