| Autor: |
Kriegelstein, Michal, Profous, David, Lyčka, Antonín, Trávníček, Zdeněk, Přibylka, Adam, Volná, Tereza, Benická, Sandra, Cankař, Petr |
| Zdroj: |
The Journal of Organic Chemistry; September 2019, Vol. 84 Issue: 18 p11911-11921, 11p |
| Abstrakt: |
Racemic 2-(2-trifluoromethyl)-1H-benzo[d]imidazol-1-yl)benzoic acid (TBBA) was synthesized in three steps from 1-fluoro-2-nitrobenzene. Target (P)- and (M)-TBBA atropisomers were stable with a racemization barrier above 30 kcal/mol. As a chiral derivatizing agent, TBBA showed much higher differences in chemical shifts (ΔδPM) than the conventional Mosher’s acid. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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