Co-targeting of endothelin-Aand vitamin D receptors: a novel strategy to ameliorate cisplatin-induced nephrotoxicity

Autor:	Abdel Moneim, Lobna M., Helmy, Maged W., El-Abhar, Hanan S.
Zdroj:	Pharmacological Reports; October 2019, Vol. 71 Issue: 5 p917-925, 9p
Abstrakt:	•A cross-talk has emerged between ET-1/ETAR and VDR in cisplatin nephrotoxicity.•BQ-123 attenuated cisplatin nephrotoxicity by reducing ET-1 and ETAR expression.•Co-targeting ET-1 and VDR provided greater renoprotection than targeting ET-1.•Alfacalcidol augmented the renoprotective effect of BQ-123.•Alfacalcidol and BQ-123 downregulated ET-1/ETAR and upregulated ETBR/VDR
Databáze:	Supplemental Index
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