| Autor: |
Li, Zhenbao, Zhu, Jiaojiao, Wang, Yongqi, Zhou, Mei, Li, Dan, Zheng, Shunzhe, Yin, LiLi, Luo, Cong, Zhang, Huicong, Zhong, Lu, Li, Wei, Wang, Jian, Gui, Shuangying, Cai, Biao, Wang, Yongjun, Sun, Jin |
| Zdroj: |
Asian Journal of Pharmaceutical Sciences; July 2020, Vol. 15 Issue: 4 p482-491, 10p |
| Abstrakt: |
The therapeutic efficiency of active targeting nanoparticulate drug delivery systems (nano-DDS) is highly compromised by the plasma proteins adsorption on nanoparticles (NPs) surface, which significantly hinders cell membrane receptors to recognize the designed ligands, and provokes the off-target toxicity and rapid clearance of NPs in vivo. Herein, we report a novel dihydroartemisinin (DHA)-decorating nano-DDS that in situspecifically recruits endogenous apolipoprotein E (apoE) on the NPs surface. The apoE-anchored corona is able to prolong PLGA-PEG2000-DHA (PPD) NPs circulation capability in blood, facilitate NPs accumulating in tumor cells by the passive enhanced permeability and retention (EPR) effect and low-density lipoprotein receptor (LDLr)-mediated target transport, and ultimately improve the in vivoantitumor activity. Our findings demonstrate that the strategy of in situregulated apoE-enriched corona ensures NPs an efficient LDLr-mediated tumor-homing chemotherapy. |
| Databáze: |
Supplemental Index |
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