| Autor: |
Ahmed, Ebrahim-Alkhalil M. A., Suliman, Ayman M. Y., Gong, Tian-Jun, Fu, Yao |
| Zdroj: |
Organic Letters; July 2019, Vol. 21 Issue: 14 p5645-5649, 5p |
| Abstrakt: |
A palladium-catalyzed cross-coupling of gem-difluorinated cyclopropanes with boronic acids, providing the corresponding arylated/alkenylated/alkylated 2-fluoroallylic scaffolds, is generated. This new approach has good functional group compatibility for both gem-difluorinated cyclopropanes and boronic acids; thus, an array of synthetic building blocks of monofluoroalkene scaffolds including conjugated fluorodiene and skipped fluorodiene gave good yields with high Z-selectivity. Moreover, proficient application was described for monofluoroalkene, whereas the corresponding alkyl fluoride was constructed through hydrogenation. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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