| Autor: |
Wenzel, B. E., Arnholdt, H., Grammerstorf, S., Gutekunst, R., Scriba, P. C. |
| Zdroj: |
European Journal of Endocrinology; August 1987, Vol. 116 Issue: 1, Number 1 Supplement 1 pS21-S26, 6p |
| Abstrakt: |
Abstract. The modulation of HLA-D expression of thyroid epithelial cells (TEC) was studied in vitro by means of immunofluorescence. Under serum-free culture conditions, TSH and TSH-receptor antibodies induce HLA-D on TECs derived from GD-patients. Serum-free culture conditions provide a higher availability of TSH-receptors by a 'right side right' polarity of the cellular morphology. There was no evidence for IFN-γ producing cell contaminations on GD-TECs. TSH in contrast to IFN-γ does not induce HLA-DQ on TECs. HLA-DQ is not displayed by spontaneously class-II antigen expressing GD-TECs. Methimazole as well as perchlorate do not suppress HLA-D expression of TECs. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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